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Over 80% of selected patients, such as EGFR mutation-positive patients, respond to gefitinib treatment; however, most patients develop acquired resistance to gefitinib within a few years.

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To verify this result in a system that is more relevant to NSCLC, we established permanently transfected cells for wild-type and mutated EGFRs using a H1299 NSCLC cell line.

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Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

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Coprimary endpoints were progression-free survival by independent central review, time-to-treatment failure, and overall survival.

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The baseline pEGFR 0 and I max were set equal to 1 based on the assumption that the phosphorylation of pEGFR was not inhibited in the absence of gefitinib and that it could be fully inactivated at sufficiently high gefitinib tumor drug concentrations, respectively.

Por tanto, si queremos abordar el hecho de que la obesidad es ahora el asesino nmero uno en el mundo, tenemos que afrontar el problema del mismo en que lo hacemos con el tabaquismo.

Either the parents are persuaded or ordered to treat their child properly as in the case of Daniel Hauser; they come to some sort of compromise that allows the child to get some treatment plus alternative healing as in the case of Abraham Cherrix; or, a depressingly common outcome, they win the right to let their child die through medical neglect, as has just happened with this First Nations girl with lymphoma.

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