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Then as a test back to Glimepiride (2mg one time); within hours same symptoms (severe headaches, stuffy nose).

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At the end of each week of the first four weeks of the trial, these patients had their dosages of Metformin hydrochloride tablets increased by 500 mg if they had failed to reach target fasting plasma glucose.

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Lantus once daily at bedtime or NPH insulin administered once or twice daily was evaluated for 28 weeks.

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