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Of the 26 patients who agreed to have the dose of azathioprine reduced to 1 mg per kilogram per day, 5 had relapses (1 each at 8, 13, 24, 25, and 26 months after the dose reduction), 1 died of a myocardial infarction 1 year after the dose reduction (), and 14 continued to be in remission for a median of 57 months (range, 24 to 77).

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Patients heterozygous for a nonfunctional TPMT allele are recommended azathioprine with a reduced dose.

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